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Wish Zahlungsmethode Г¤ndern

However, the two enantiomers have been shown to exhibit different kinetics. The disposition of MDMA may also be stereoselective, with the S-enantiomer having a shorter elimination half-life and greater excretion than the R-enantiomer.

MDMA is in the substituted methylenedioxyphenethylamine and substituted amphetamine classes of chemicals. As a free base , MDMA is a colorless oil insoluble in water.

There are numerous methods available to synthesize MDMA via different intermediates. MDP2P in turn is generally synthesized from piperonal , safrole or isosafrole.

Another method uses the Wacker process to oxidize safrole directly to the MDP2P intermediate with a palladium catalyst. MDMA and MDA may be quantitated in blood, plasma or urine to monitor for use, confirm a diagnosis of poisoning or assist in the forensic investigation of a traffic or other criminal violation or a sudden death.

Some drug abuse screening programs rely on hair, saliva, or sweat as specimens. Most commercial amphetamine immunoassay screening tests cross-react significantly with MDMA or its major metabolites, but chromatographic techniques can easily distinguish and separately measure each of these substances.

At the time, Merck was interested in developing substances that stopped abnormal bleeding. Merck wanted to avoid an existing patent held by Bayer for one such compound: hydrastinine.

Köllisch developed a preparation of a hydrastinine analogue , methylhydrastinine, at the request of fellow lab members, Walther Beckh and Otto Wolfes.

MDMA called methylsafrylamin, safrylmethylamin or N-Methyl-a-Methylhomopiperonylamin in Merck laboratory reports was an intermediate compound in the synthesis of methylhydrastinine.

Merck was not interested in MDMA itself at the time. Merck records indicate its researchers returned to the compound sporadically.

Compared to ephedrine, Oberlin observed that it had similar effects on vascular smooth muscle tissue, stronger effects at the uterus, and no "local effect at the eye".

MDMA was also found to have effects on blood sugar levels comparable to high doses of ephedrine. Oberlin concluded that the effects of MDMA were not limited to the sympathetic nervous system.

Research was stopped "particularly due to a strong price increase of safrylmethylamine", which was still used as an intermediate in methylhydrastinine synthesis.

Albert van Schoor performed simple toxicological tests with the drug in , most likely while researching new stimulants or circulatory medications. After pharmacological studies, research on MDMA was not continued.

In and , the United States Army commissioned a study of toxicity and behavioral effects in animals injected with mescaline and several analogues, including MDMA.

Conducted at the University of Michigan in Ann Arbor , these investigations were declassified in October and published in American chemist and psychopharmacologist Alexander Shulgin reported he synthesized MDMA in while researching methylenedioxy compounds at Dow Chemical Company , but did not test the psychoactivity of the compound at this time.

This individual later provided these instructions to a client in the Midwest. Shulgin first heard of the psychoactive effects of N-methylated MDA around from a young student who reported "amphetamine-like content".

Nichols published a report on the drug's psychoactive effect in humans. They described MDMA as inducing "an easily controlled altered state of consciousness with emotional and sensual overtones" comparable "to marijuana, to psilocybin devoid of the hallucinatory component, or to low levels of MDA".

While not finding his own experiences with MDMA particularly powerful, [] [] Shulgin was impressed with the drug's disinhibiting effects and thought it could be useful in therapy.

When he tried the drug in , Zeff was impressed with the effects of MDMA and came out of his semi-retirement to promote its use in therapy.

Over the following years, Zeff traveled around the United States and occasionally to Europe, eventually training an estimated four thousand psychotherapists in the therapeutic use of MDMA.

Psychotherapists who used MDMA believed the drug eliminated the typical fear response and increased communication. Sessions were usually held in the home of the patient or the therapist.

The role of the therapist was minimized in favor of patient self-discovery accompanied by MDMA induced feelings of empathy. Depression, substance abuse, relationship problems, premenstrual syndrome, and autism were among several psychiatric disorders MDMA assisted therapy was reported to treat.

Anecdotally, MDMA was said to greatly accelerate therapy. Only later was the term "ecstasy" used for it, coinciding with rising opposition to its use.

In the late s and early s, "Adam" spread through personal networks of psychotherapists, psychiatrists, users of psychedelics, and yuppies.

A small recreational market for MDMA developed by the late s, [] consuming perhaps 10, doses in Having commenced production in , this "Boston Group" did not keep up with growing demand and shortages frequently occurred.

Perceiving a business opportunity, Michael Clegg, the Southwest distributor for the Boston Group, started his own "Texas Group" backed financially by Texas friends.

Recreational use also increased after several cocaine dealers switched to distributing MDMA following experiences with the drug. In the next month, the World Health Organization identified MDMA as the only substance out of twenty phenethylamines to be seized a significant number of times.

Young presiding. Sensational media attention was given to the proposed criminalization and the reaction of MDMA proponents, effectively advertising the drug.

The agency cited increased distribution in Texas, escalating street use, and new evidence of MDA an analog of MDMA neurotoxicity as reasons for the emergency measure.

Lawn overruled and classified the drug as Schedule I. Despite this, less than a month later Lawn reviewed the evidence and reclassified MDMA as Schedule I again, claiming that the expert testimony of several psychiatrists claiming over cases where MDMA had been used in a therapeutic context with positive results could be dismissed because they weren't published in medical journals.

While engaged in scheduling debates in the United States, the DEA also pushed for international scheduling.

The committee made this recommendation on the basis of the pharmacological similarity of MDMA to previously scheduled drugs, reports of illicit trafficking in Canada, drug seizures in the United States, and lack of well-defined therapeutic use.

While intrigued by reports of psychotherapeutic uses for the drug, the committee viewed the studies as lacking appropriate methodological design and encouraged further research.

Committee chairman Paul Grof dissented, believing international control was not warranted at the time and a recommendation should await further therapeutic data.

The use of MDMA in Texas clubs declined rapidly after criminalization, although by the drug remained popular among young middle-class whites and in nightclubs.

Since the mids, MDMA has become the most widely used amphetamine-type drug by college students and teenagers. Paste this HTML code on your site to embed.

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